A new case of mu heavy chain disease: clinical and immunochemical studies.

A new case of mu heavy chain disease is Appreciable amounts of kappa chains described. The patient, a 48-yr-old Italian were also detected in the urine. The mu housewife, suffered from chronic lymphochain disease protein had a molecular cytic leukemia of 3 yr duration with weight of approximately 54,000 and a anemia and hepcstosplenomegaly, but no heterogeneous NH2 terminus, alanine peripheral lymph node enlargement. being the main identifiable residue. The Serum protein studies disclosed a small NH3 terminal of the kappa chain was M component with gamma-i mobility glutamic acid. No J chain was detected ascribable to free kappa chains, hypeby polyacrylamide electrophoresis of the gammaglobulmnemia, and mu chain frogpartially reduced and alkylated mu chain ments with abnormally anodic mobility. disease protein.